Type-1A Topoisomerases
Type-1A topoisomerases interact and cleave single-stranded DNA regions.......,
..................
E.coli topo I / E.coli topo III / Sc topo III / Human topo IIIa / human topo IIIb
Type-1B Topoisomerases
Type-1B topoisomerases interact with duplex DNA and break one of the strands allowing one severed DNA end to pivot about the uncleaved strand.
.............
Type-2A Topoisomerases
Type-2A topoisomerases are functional homodimers and use ATP.
..............
DNA Gyrase
